“Tasting” fructose with pancreatic beta-cells: modulation of insulin release by sweet taste receptor signaling and its role in metabolic diseases
نویسندگان
چکیده
Background Although glucose is indispensable for the stimulation of insulin release, numerous other insulin secretagogues have been identified. For instance, the dietary monosaccharide fructose potentiates insulin secretion in vitro, but the mechanism and physiological significance remains unclear. The T1R2-T1R3 heterodimer of G protein-coupled receptors mediates sweet sensing in the tongue and ablation of either subunit obliterates sweet taste. We hypothesized that the effects of fructose on insulin release may be mediated by sweet taste receptors (TRs) on beta-cells.
منابع مشابه
Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.
Postprandial insulin release is regulated by glucose, but other circulating nutrients may target beta cells and potentiate glucose-stimulated insulin secretion via distinct signaling pathways. We demonstrate that fructose activates sweet taste receptors (TRs) on beta cells and synergizes with glucose to amplify insulin release in human and mouse islets. Genetic ablation of the sweet TR protein ...
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